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KMID : 1094020230400040276
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Journal of Veterinary Clinics
2023 Volume.40 No. 4 p.276 ~ p.282
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Evaluation of Treatment with a Combination of Prednisolone and Mycophenolate Mofetil for Dogs with Immune-Mediated Polyarthritis
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Kim Jung-Il
Kim Jin-Young
Bae Jeong-Yeol
Joung Guk-Il
Song Joong-Hyun
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Abstract
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Immune-mediated polyarthritis (IMPA) is an inflammatory, noninfectious disease that affects two or more joints in dogs. Immunosuppressive doses of prednisolone are considered the initial treatment choice for dogs with IMPA. However, few reports have described the combination of mycophenolate mofetil and prednisolone for treating dogs with IMPA. In this report, we described the cases of three dogs treated with a combination of mycophenolate mofetil and prednisolone. The clinical signs were alleviated in all cases, and C-reactive protein levels were reduced after treatment. Our results show that combination therapy of mycophenolate mofetil and prednisolone is effective in managing IMPA. However, careful monitoring of the potential adverse effects, including sporadic infections and metabolic diseases, is necessary. In addition, screening tests and appropriate treatments are necessary for proteinuria, a common complication in dogs with IMPA.
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KEYWORD
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dog, immune-mediated polyarthritis, mycophenolate mofetil, prednisolone, lameness
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